Mechanical Power Density Predicts Prolonged Ventilation Following Double Lung Transplantation

Prolonged mechanical ventilation (PMV) after lung transplantation poses several risks, including higher tracheostomy rates and increased in-hospital mortality. Mechanical power (MP) of artificial unifies the ventilatory variables that determine gas exchange may be related to allograft function following transplant, affecting ventilator weaning. We retrospectively analyzed consecutive double transplant recipients at a national center, ventilated through endotracheal tubes upon ICU admission, excluding those receiving extracorporeal support. MP derived indexes assessed up 36 h were correlated with invasive duration using Spearman’s coefficient, we conducted receiver operating characteristic (ROC) curve analysis evaluate accuracy in predicting PMV (>72 h), expressed as area under ROC (AUROC). occurred 82 (35%) out 237 cases. was significantly (Spearman’s ρ = 0.252 [95% CI 0.129–0.369], p < 0.01), density (MP normalized lung-thorax compliance) demonstrating strongest correlation ( 0.452 [0.345–0.548], 0.01) enhancing prediction (AUROC 0.78 0.72–0.83], compared 0.66 [0.60–0.72], 0.01). help identify patients risk for transplantation.